Health & Environmental Research Online (HERO)


Print Feedback Export to File
2250966 
Journal Article 
In vivo-in vitro comparisons in the transdermal delivery of nitroglycerin 
Hadgraft, J; Beutner, D; Wolff, HM 
1993 
Yes 
International Journal of Pharmaceutics
ISSN: 0378-5173
EISSN: 1873-3476 
IPA/93/1030596 
J 
REF 4 
eng 
IPA COPYRIGHT: ASHP Reported correlations between the in vitro release of transdermal patch formulations of nitroglycerin, Deponit, and Nitro-Dur II, across human skin dermatomed to 220 mum and plasma levels in vivo are discussed. It was noted that there was very good agreement between predicted and experimentally determined values for both preparations. This showed that the in vitro method linked with clearance kinetics can provide information about the delivery of the drug over the time course of application. It was concluded that, for the delivery of transdermal nitroglycerin, the method in which drug release was assessed with the patch in contact with human skin dermatomed to 220 mum, there appears to be very good in vitro-in vivo correlation.