Stability of high concentration dopamine hydrochloride, norepinephrine bitartrate, epinephrine hydrochloride, and nitroglycerin in dextrose 5 percent and water | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

2251027

Reference Type

Technical Report

Title

Stability of high concentration dopamine hydrochloride, norepinephrine bitartrate, epinephrine hydrochloride, and nitroglycerin in dextrose 5 percent and water

Author(s)

Peddicord, TE; Zumbrunnen, TL; Warner, DJ; Webb, L; Olsen, KM

Year

1995

Report Number

IPA/95/1086585

Volume

VOL 30 ISS Dec 1995

Issue

Language

eng

Abstract

IPA COPYRIGHT: ASHP The purpose is to evaluate the stability of concentrated dopamine, norepinephrine, epinephrine, and nitroglycerin in admixtures containing dextrose 5 percent and water under conditions found in the intensive care unit. Analysis was accomplished utilizing high performance liquid chromatography. Standard solution calibration plots were found to be linear by regression analysis (r=0.999) of sample concentrations (dopamine 6.4 mg/ml, norepinephrine 64 mcg/ml, epinephrine 100 mcg/ml, and nitroglycerin 1 mg/ml). Statistical significance was determined by one-way analysis of variance with repeated measures (significance less than or equal to 0.05). Epinephrine and norepinephrine were shown to be stable (P=0.7937 and 0.9245, respectively) over 24 hours at the concentrations and conditions described. Nitroglycerin and dopamine results are pending.