US EPA

2251140 

Journal Article 

A Note on the Haemodynamic Effects of Nitroglycerine and Related Substances in Normal Subjects 

Nordenfelt, I; Westling, H 

1967 

Yes 

Acta Medica Scandinavica
ISSN: 0001-6101 

NIOSH/00130421 

472 

81-87 

The hemodynamic effects of nitroglycerine (55630) were measured in normal adult males and were compared to previous results from persons with coronary heart disease. The response of five normal males to nitroglycerine was recorded during three different work loads. The influence of posture on the effects of nitroglycerine were measured in 13 normal males. Nitroglycerine was administered sublingually at varying intervals during the exercise tests. Arterial pressures were recorded, mean arterial pressures were obtained by electrical integration, and measurements of the effects of posture were taken by the auscultatory method. The major changes seen in the five males were tachycardia, reduced stroke volume, and a fall in systolic blood pressure, with larger effects on cardiac output and stroke volume seen at the highest work load. The responses were generally the same as those previously seen in coronary disease patients. When the effects of nitroglycerine on stroke volume in normal patients were compared to values from coronary patients at rest and during exercise, a distinct difference was seen in resting patients. A fall in stroke volume after nitroglycerine was seen only in coronary patients, while no effect of nitroglycerine was found in reclining normal patients. Tachycardia and a fall in pulse amplitude were found in standing normal comparisons. The authors conclude that in normal persons nitroglycerine during exercise has the same effects seen in coronary heart disease patients; it reduces stroke volume and cardiac output, and increases heart rate.