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2251214 
Journal Article 
Further Experiments On The Prevention Of Motion Sickness 
Glaser, EM; Hervey, GR 
1952 
1 
The Lancet
ISSN: 0140-6736
EISSN: 1474-547X 
NIOSH/00138232 
1 
490-492 
The effect of hyoscine (51343) on prevention of motion sickness were investigated in 150 soldiers. Subjects were placed in small rubber floats in a pool with artificially induced waves. In the first experiment, 102 subjects were given hyoscine-hydrobromide (114498) at (HH) 1 milligram (mg), 35mg promethazine-hydrochloride (58333) (PH), 1mg HH with 25mg PH, or 0.65mg HH with 15mg PH, or with 50mg mannitol-hexanitrate (15825704). Lactose was given to some subjects as a placebo. Subjects were rotated and exposed to different substances at intervals not less than 48 hours apart. A second experiment was conducted using 48 soldiers given HH on various days of a 6 day exposure period. On days 4 and 5 no HH was given; if subjects felt sick they were given 0.6mg glyceryl-trinitrate (55630) or lactose. In the first experiment, of 101 subjects given a placebo, 36 vomited. In 98 subjects given HH, 3 vomited; of 99 given 35mg PH, 13 vomited. A 1mg dose of HH with 15mg PH produced vomiting in 2 of 97 subjects, and doses of 0.65 and 15mg, respectively, produced vomiting in 4 of 99 subjects. Of 96 subjects given the combination of drugs that included mannitol, 6 vomited. Subjects exposed to hyoscine 1.25 hours before exposure to motion were 88 percent protected, whereas those given the drug 5 to 10 minutes before motion were 69 percent protected. Of 16 subjects given nitroglycerin before motion exposure, 8 vomited; 10 of 16 vomited after the placebo. The authors conclude that all substances containing hyoscine are more effective than promethazine in preventing motion sickness.