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2251394 
Technical Report 
TRANSPLACENTAL AMINOPHYLLINE TOXICITY IN A NEONATE 
Yeh, TF; Pildes, RS 
1977 
1 
The Lancet
ISSN: 0140-6736
EISSN: 1474-547X 
ETICBACK/4539 
910 
REF 5 
910 
eng 
IPA COPYRIGHT: ASHP Reported is the case of a neonate who presented with symptoms of irritability, vomiting, and jitteriness, possibly related to maternal ingestion of aminophylline. The mother had had symptoms of asthma on and off for the previous 3 yr. During this pregnancy she had had a few episodes of wheezing for which she took aminophylline intermittently. One day before delivery the patient came to the emergency room because of shortness of breath, wheezing, and abdominal pain and was given several drugs for her respiratory problem including aminophylline (500 mg by suppository and 100 mg by mouth), frusemide (furosemide), and nitroglycerin. Aminophylline (100 mg) was subsequently given every 4 hr. The last dose was given one hr before delivery.