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2251551 
Journal Article 
Bupropion mimics a transient ischemic attack 
Humma, LM; Swims, MP 
1999 
Yes 
Annals of Pharmacotherapy
ISSN: 1060-0280
EISSN: 1542-6270 
IPA/99/1174079 
Pharmacother 
REF 10 
305-307 
IPA COPYRIGHT: ASHP The case of a 67-yr-old man with a history of ischemic stroke who developed symptoms suggestive of transient ischemic attacks (TIAs) 1 wk after starting treatment with 100 mg of bupropion 3 times daily for smoking cessation is presented. Concomitant therapy included captopril, metoprolol, furosemide, cimetidine, diltiazem, aspirin, nitroglycerin, beclomethasone, albuterol, ipratropium, and ticlopidine. The patient presented to the hospital with symptoms of paresthesia, dizziness, tinnitus, confusion, and gait impairment. He was diagnosed with presumptive TIAs and bupropion was stopped at the time of admission. Testing for vertebral basilar artery disease was negative. The patient's symptoms ceased after the day of admission, and he was discharged 2 days later. One month later, he reported remaining symptom free until 2 days after discharge when he restarted bupropion on his own. Within 1 h of the first dose, he experienced symptoms mimicking a TIA that resolved after about 30 min. The patient stopped bupropion. Nine months later, he remained symptom free.