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2251675 
Technical Report 
Stevens-Johnson syndrome associated with diltiazem 
Taylor, JW; Cleary, JD; Atkinson, RC 
1990 
IPA/91/933274 
Pharm 
REF 20 
948-950 
eng 
IPA COPYRIGHT: ASHP A case of Stevens-Johnson syndrome that occurred after less than 15 days of diltiazem therapy and that was confirmed by rechallenge is described in a 58-yr-old man who was taking diltiazem along with isosorbide dinitrate, aspirin, and nitroglycerin for angina. The use of nifedipine or verapamil in this patient did not cause reappearance of the syndrome. When diltiazem causes a severe cutaneous reaction, cautious use of other calcium channel blockers is recommended.