Health & Environmental Research Online (HERO)


Print Feedback Export to File
2252151 
Journal Article 
Vascular Responsiveness in Patients With Chronic Obstructive Pulmonary Disease (COPD) 
Simsolo, C; Blum, A 
2014 
Yes 
Chest
ISSN: 0012-3692
EISSN: 1931-3543 
145 
3 Suppl 
398A 
English 
24638555 
SESSION TITLE: COPD Comorbidity PostersSESSION TYPE: Poster PresentationsPRESENTED ON: Saturday, March 22, 2014 at 01:15 PM - 02:15 PMPURPOSE: Our aim was to study the vascular reactivity of patients with stable COPD and to try to correlate endothelial dysfunction, vascular reactivity and functional capacity of these patients that eventually may lead to cardiovascular mortality

METHODS: This was a prospective study. Twenty-three consecutive ambulatory COPD patients were enrolled. All were smoking men, aged 64.4 ± 8.4 years. Twenty-two healthy volunteers aged 44.7 ± 11.7 years, BMI of 25.2 ± 4.2, height of 172 ± 8 cm served as the control group. Vascular studies included endothelial function and ankle brachial index.

RESULTS: Baseline diameter of the brachial artery was larger in COPD patients compared with controls. The absolute change in diameter post hyperemia was significantly less in patients (0.004 ± 0.02 cm vs. 0.05 ± 0.02 cm, p < 0.001) and COPD patients responded to hyperemia by constriction instead of dilatation (FMD% was - 0.6 ± 6.3% in patients vs. 15.6 ± 7.6% in controls, p < 0.001). There was no difference in ABI in patients and controls (0.95 ± 0.26 vs. 1.06 ± 0.16, p = 0.07).

CONCLUSIONS: We found that patients with COPD have dilated arteries, have impaired ability to respond to high shear stress that triggers nitric oxide dependent flow mediated dilatation, and have also impaired ability to function - represented by the poor 6 minute walk test.

CLINICAL IMPLICATIONS: We found that patients with COPD have dilated arteries, have impaired ability to respond to high shear stress that triggers nitric oxide dependent flow mediated dilatation, and performed a poor 6 minute walk test.

DISCLOSURE: The following authors have nothing to disclose: Claudia Simsolo, Arnon BlumNo Product/Research Disclosure Information.