US EPA

2262596 

Journal Article 

Abstract 

Fractional exhaled nitric oxide does not correlate with functional measures in pre-school wheezy children 

Bar-Yishay, E; Matyashchuk, E; Mussaffi, H; Prais, D; Steuer, G; Mei-Zahav, M; Hananya, S; Blau, H 

2010 

Yes 

American Journal of Respiratory and Critical Care Medicine
ISSN: 1073-449X
EISSN: 1535-4970 

181 

A3922 

English 

10.1164/ajrccm-conference.2010.181.1_MeetingAbstracts.A3922 

WOS:000208771003271 

is part of a larger document 3452678 Proceedings of the American Thoracic Society 2010 International Conference, May 14-19, 2010, New Orleans

INTRODUCTION: Fractional exhaled nitric oxide (FeNO) is a biomarker of airway inflammation and has been shown to indicate the severity of disease in asthmatic patients and to decrease during treatment with anti inflammatory agents. Results of past investigations on the possible relation between FeNO and the spirometric response to bronchodilator response (BD) are scarce and equivocal. There are no studies that looked at the association between FeNO and changes in indiced obtained by the forced oscillation technique (FOT).

STUDY OBJECTIVES: To determine if FeNO values correlate with baseline lung function or with bronchodilator response in pre-school children.

PATIENTS AND METHODS: 55 pre-school children wheezing of various etiologies, including recurrent pneumonia, chronic cough and asthma. Mean age 4.1±0.8 (range 2-6 years). Tests were repeated after BD (salbutamol MDI, 2X100mcg/puff via spacer with mask). Lung function was evaluated by spirometry and by FOT (Quark i2m, Chess mT, Belgium) at baseline and following BD. Degree of airway inflammation was evaluated by FeNO using a fast-response chemoluminescence analyzer (CLD 77 AM; Eco Medics; Duernten, Switzerland).

RESULTS: Baseline lung function by FOT (R6, X6, Slope) tended to decrease, and Fres tended to increase, with increasing FeNO values but none of the correlations reached significant level. Similarly, lung function by spirometry (FEV1 and FEF50) tended to decrease with increasing FeNO values but the correlations did not reach significant level. Likewise, FeNO values did not correlate with the magnitude of response to BD as measured by FOT parameters (n=44; p= 0.49 for R6), nor with changes in FEV1 (p=0.14) but showed a weak correlation with FEF50 (p=0.04). (n=39).

CONCLUSIONS: In wheezy children of preschool age 1) FeNO levels do not correlate with baseline lung function derived from either spirometry or from FOT, and 2) FeNO has a poor predictive power of the response to bronchodilator therapy. 

American Thoracic Society 2010 International Conference 

New Orleans, LA 

May 14-19, 2010