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2262603 
Journal Article 
Abstract 
The relationship of exhaled nitric oxide, pulmonary function and asthma in the Southern California Children's Health Study 
Bastain, TM; Mcconnell, R; Islam, T; Berhane, KT; Gauderman, WJ; Rappaport, EB; Avol, EL; Linn, WS; Gilliland, FD 
2010 
Yes 
American Journal of Respiratory and Critical Care Medicine
ISSN: 1073-449X
EISSN: 1535-4970 
181 
A3312 
English 
WOS:000208771002423 
is part of a larger document 3452678 Proceedings of the American Thoracic Society 2010 International Conference, May 14-19, 2010, New Orleans
RATIONALE: Exhaled nitric oxide (FeNO) is a non-invasive biomarker for airway inflammation that can be utilized in large population-based studies. The Southern California Children’s Health Study (CHS) provided an opportunity to examine the relationship between airway inflammation and pulmonary function in healthy children and children with asthma.

METHODS: In this cross-sectional study, we examined 1559 schoolchildren (246 with asthma) from the CHS (mean age: 11.2 years, SD: 0.6 years). We measured FeNO using EcoMedics NO analyzers with ambient NO scrubbers at standard flows of 50 ml/sec. Maximal expiratory performance was measured by trained field technicians using ScreenStar (pressure transducer-based) spirometers. Linear regression was used to examine the relationship of FeNO and several key spirometric measures.

RESULTS: Among children with asthma, deficits in pulmonary function level were associated with elevated exhaled nitric oxide. Among children with asthma, there were increasing deficits in maximum mid-expiratory flow (MMEF) with increasing quartiles of FeNO (1.4%; 2.7%; 5.6%; 7.7% for FeNO quartiles 1-4, respectively), after adjustment for potential confounders, including recent medication use. A similar pattern of effects was observed for FEV1, FEF75, and FEV1/FVC ratio. Among children without asthma, there was no relationship between FeNO and pulmonary function.

CONCLUSIONS: We found that among children with asthma, elevated nitric oxide was associated with deficits in pulmonary function. These results suggest that FeNO has potential for distinguishing those at greater risk of pulmonary function deficits, especially among children with asthma. 
American Thoracic Society 2010 International Conference 
New Orleans, LA 
May 14-19, 2010 
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