US EPA

2262622 

Journal Article 

Abstract 

Fraction of exhaled nitric oxide (FeNO) and correlation to different copd subgroups - a cross-sectional study 

Bazeghi-Roberts, N; Vestbo, J; Gerds, T; Budtz-Joergensen, E; Hove, J 

2010 

Yes 

American Journal of Respiratory and Critical Care Medicine
ISSN: 1073-449X
EISSN: 1535-4970 

181 

A1555 

English 

10.1164/ajrccm-conference.2010.181.1_MeetingAbstracts.A1555 

WOS:000208771000555 

is part of a larger document 3452678 Proceedings of the American Thoracic Society 2010 International Conference, May 14-19, 2010, New Orleans

Background: Although there has been widespread interest in the use of non-invasive biomarkers such as (FeNO) for the assessment of airway inflammation in chronic obstructive pulmonary disease (COPD), its usefulness is still controversial.

Aim: In this cross-sectional study we aimed to examine whether FeNO levels correlate with different clinically meaningful subgroups of COPD.

Patients and Method: Ninety one (91) COPD patients recruited with FEV ranging from 17 77%. Multiple flow rates FeNO at 10, 30, 50, 100, and 200 mL·s^-1 has been performed and two compartment nonlinear modelling was used for calculation of diffusion Capacity (D), alveolar NO concentration (Calv) and airway wall NO concentration (Cw). We examined the following subgroups of COPD: 1) Patients with mild emphysema, (>5% low attenuation on CT) (n=73), 2) Patients with severe emphysema, (>10% low attenuation on CT) (n=61), 3) Patients with chronic bronchitis, defined by cough and phlegm for 3 months per year for at least 2 years according to the ATS-DLD questionnaire (n=51), 4) Patients with frequent exacerbations, defined as 2 or more exacerbations in the year prior to inclusion(n=46), 5) Patients with loss of lean body mass, defined as body mass index (BMI)< 21 kg/m^2 (n=16)or fat-free mass index (FFMI) < 16 kg/m^2 for men and < 15 kg/m^2 for women (n=25). As we used markers of systemic inflammation also relevant to cardiac disease we also examined 6) 2 patients with any positive history of CVD (n=39). We used an advanced non-linear mixed model adjusted for age, gender and smoking.

Results: Our analyses showed that there were no differences in D, Calv or Cw among these subgroups. The resuls were the same by a simple or more advanced non-linear mixed model which took missing value better in account.

Conclusion: This study questions the relevance of using FeNO to evaluate local inflammation in different COPD phenotypes and indicates a need for developing novel biomarkers that may assist us both in the research laboratory and daily clinical practice. 

American Thoracic Society 2010 International Conference 

New Orleans, LA 

May 14-19, 2010