Exhaled nitric oxide and diffusion capacity of the lung for carbon monoxide in chronic liver disease | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

2265490

Reference Type

Journal Article

Subtype

Abstract

Title

Exhaled nitric oxide and diffusion capacity of the lung for carbon monoxide in chronic liver disease

Author(s)

Lee, JH; Lee, BH; Kim, SH

Year

2010

Is Peer Reviewed?

Yes

Journal

American Journal of Respiratory and Critical Care Medicine
ISSN: 1073-449X
EISSN: 1535-4970

Volume

181

Page Numbers

A6344

Language

English

DOI

10.1164/ajrccm-conference.2010.181.1_MeetingAbstracts.A6344

Web of Science Id

WOS:000208771004703

Relationship(s)

is part of a larger document 3452678 Proceedings of the American Thoracic Society 2010 International Conference, May 14-19, 2010, New Orleans

Abstract

Introduction: Impaired arterial oxygenation is commonly present in patients with cirrhosis. Intrapulmonary vascular dilatations and arterio-venous shunts are thought to be the pathological mechanisms of oxygenation abnormalities. Nitric oxide (NO) is a powerful local vasodilator, and has recently ascended to the top of the list of possible substances in the oxygen abnormalities of cirrhosis.

Methods: Eighty three patients with chronic liver disease and ten healthy persons were included. Complete blood count, general biochemistry, spirometry with diffusion capacity of the lung for carbon monoxide (DLCO) was performed to all of the subjects. Endogenously produced NO in exhaled gas was measured on a chemiluminescence analyzer. Past and current medical histories of the subjects were taken.

Result: DLCO in cirrhosis patients was decreased than healthy control (16.2±4.7 vs 21.8±6.5mmol/min/kPa, p<0.001). However, exhaled NO concentrations were not different between two groups (51.1±22.7 vs 37.5±13.1ppb, p=0.75). DLCO was more decreased in severe chronic liver disease groups (21.8±6.5 in control, 17.4±6.6 in chronic hepatitis, 16.9±4.5 in Child A, 15.8±4.5 in Child B, 14.7±6.2 in Child C; p=0.025). Exhaled NO concentrations were not different in these groups (37.5±13.1 in control, 45.3±16.7 in chronic hepatitis, 52.8±23.6 in Child A, 49.4±20.2 in Child B, 49.7±30.6 in Child C; p=0.377).

Conclusion: DLCO in cirrhosis patients was decreased than healthy control, and which was correlated with severities of chronic liver disease. Exhaled NO concentrations were not different between cirrhosis and healthy control.

Conference Name

American Thoracic Society 2010 International Conference

Conference Location

New Orleans, LA

Conference Dates

May 14-19, 2010