Health & Environmental Research Online (HERO)


Print Feedback Export to File
2267686 
Journal Article 
Abstract 
Peripheral (alveolar) nitric oxide concentration correlates strongly with asthma control in a pediatric longitudinal study 
Shi, Y; Puckett, J; Galant, S; Aledia, A; George, SC 
2010 
Yes 
American Journal of Respiratory and Critical Care Medicine
ISSN: 1073-449X
EISSN: 1535-4970 
181 
A3724 
English 
WOS:000208771003081 
is part of a larger document 3452678 Proceedings of the American Thoracic Society 2010 International Conference, May 14-19, 2010, New Orleans
BACKGROUND. Exhaled nitric oxide (eNO) is a marker of pulmonary inflammation in asthma patients. eNO can be partitioned into proximal airway NO (J’aw_NO) and distal airway/alveolar NO (CA_NO) contributions. However, these parameters have not been examined in longitudinal clinical trials.

HYPOTHESIS: Independent of inhaled corticosteroid use, a change in asthma control correlates with a change in CA_NO in children with mild asthma.

METHODS: 25 newly diagnosed steroid-naïve children with asthma were enrolled in the study. All children were prescribed inhaled corticosteroids at the initial evaluation (visit #1), and returned within 10 weeks (visit #2). Symptoms (asthma control test; ACT, score≤19 is poor control), spirometry (including the bronchodilator response, BDR), and exhaled NO at three flows (50, 100, and 200 ml/s) were collected at each visit. A two-compartment model of NO exchange that considers axial diffusion was used to estimate J’aw_NO and CA_NO. Multiple linear regression was applied to characterize the correlations between ACT score and endpoints of spirometry and exhaled nitric oxide.

RESULTS: ACT, CA_NO, J’aw_NO and BDR were all significantly improved (p<0.01) at visit #2 in the 19 children compliant with medication. From these 19 children, ACT correlated with CA_NO (p=0.0002) and FEV1 (p=0.029) at both visits; however, the change in ACT was only correlated with a change in CA (0.0182). When data from all 25 children were examined, no NO change in the correlations were noted with the exception that ACT correlated with BDR (p=0.017).

CONCLUSIONS: In children newly diagnosed with asthma, asthma control at baseline and following initiation of therapy correlates most strongly with peripheral (distal airway/alveolar) nitric oxide concentration. 
American Thoracic Society 2010 International Conference 
New Orleans, LA 
May 14-19, 2010 
• LitSearch-NOx (2024)
     Keyword Search
          Toxicology
               March 2014-November 2016