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2270395 
Journal Article 
Aspirin: a review of its neurobiological properties and therapeutic potential for mental illness 
Berk, M; Dean, O; Drexhage, H; Mcneil, JJ; Moylan, S; O'Neil, A; Davey, CG; Sanna, L; Maes, M 
2013 
Yes 
BMC Medicine
ISSN: 1741-7015
EISSN: 17417015 
11 
23506529 
WOS:000323166800001 
There is compelling evidence to support an aetiological role for inflammation, oxidative and nitrosative stress (O&NS), and mitochondrial dysfunction in the pathophysiology of major neuropsychiatric disorders, including depression, schizophrenia, bipolar disorder, and Alzheimer's disease (AD). These may represent new pathways for therapy. Aspirin is a non-steroidal anti-inflammatory drug that is an irreversible inhibitor of both cyclooxygenase (COX)-1 and COX-2, It stimulates endogenous production of anti-inflammatory regulatory 'braking signals', including lipoxins, which dampen the inflammatory response and reduce levels of inflammatory biomarkers, including C-reactive protein, tumor necrosis factor-a and interleukin (IL)-6, but not negative immunoregulatory cytokines, such as IL-4 and IL-10. Aspirin can reduce oxidative stress and protect against oxidative damage. Early evidence suggests there are beneficial effects of aspirin in preclinical and clinical studies in mood disorders and schizophrenia, and epidemiological data suggests that high-dose aspirin is associated with a reduced risk of AD. Aspirin, one of the oldest agents in medicine, is a potential new therapy for a range of neuropsychiatric disorders, and may provide proof-of-principle support for the role of inflammation and O&NS in the pathophysiology of this diverse group of disorders. 
aspirin; depression; schizophrenia; dementia; inflammation; cytokines; neuroprogression; treatment; COX