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Citation
Tags
HERO ID
2270557
Reference Type
Journal Article
Title
Pulmonary Hypertension in CKD
Author(s)
Bolignano, D; Rastelli, S; Agarwal, R; Fliser, D; Massy, Z; Ortiz, A; Wiecek, A; Martinez-Castelao, A; Covic, A; Goldsmith, D; Suleymanlar, G; Lindholm, B; Parati, G; Sicari, R; Gargani, L; Mallamaci, F; London, G; Zoccali, C
Year
2013
Is Peer Reviewed?
Yes
Journal
American Journal of Kidney Diseases
ISSN:
0272-6386
EISSN:
1523-6838
Volume
61
Issue
4
Page Numbers
612-622
PMID
23164943
DOI
10.1053/j.ajkd.2012.07.029
Web of Science Id
WOS:000317274900355
Abstract
Pulmonary arterial hypertension is a rare disease often associated with positive antinuclear antibody and high mortality. Pulmonary hypertension, which rarely is severe, occurs frequently in patients with chronic kidney disease (CKD). The prevalence of pulmonary hypertension ranges from 9%-39% in individuals with stage 5 CKD, 18.8%-68.8% in hemodialysis patients, and 0%-42% in patients on peritoneal dialysis therapy. No epidemiologic data are available yet for earlier stages of CKD. Pulmonary hypertension in patients with CKD may be induced and/or aggravated by left ventricular disorders and risk factors typical of CKD, including volume overload, an arteriovenous fistula, sleep-disordered breathing, exposure to dialysis membranes, endothelial dysfunction, vascular calcification and stiffening, and severe anemia. No specific intervention trial aimed at reducing pulmonary hypertension in patients with CKD has been performed to date. Correcting volume overload and treating left ventricular disorders are factors of paramount importance for relieving pulmonary hypertension in patients with CKD. Preventing pulmonary hypertension in this population is crucial because even kidney transplantation may not reverse the high mortality associated with established pulmonary hypertension. Am J Kidney Dis. 61(4): 612-622. (C) 2013 by the National Kidney Foundation, Inc.
Keywords
Pulmonary hypertension; chronic kidney disease; hemodialysis; peritoneal dialysis
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