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2273270 
Journal Article 
The performance of an orthosilicic acid-releasing silica gel fiber fleece in wound healing 
Grotheer, V; Goergens, M; Fuchs, PC; Dunda, S; Pallua, N; Windolf, J; Suschek, CV 
2013 
Yes 
Biomaterials
ISSN: 0142-9612
EISSN: 1878-5905 
34 
30 
7314-7327 
23830471 
WOS:000322931900010 
In the present work, we have examined the impact of an inorganic orthosilicic acid-releasing spun fiber fleece (SIFIB) on wound closure in a porcine wound model in vivo as well as on wound healing-relevant parameters in vitro. In vivo SIFIB was completely bio-degradable and had no negative effects on wound closure or the wound healing process. In the in vitro experiments, SIFIB had no negative effects on proliferation of human skin fibroblast (FB) and endothelial cell (EC) cultures but strongly retarded the growth of the human monocyte cell line THP-1, and effectively inhibited human skin keratinocyte (K) proliferation, which based on significantly enhanced KC differentiation. Furthermore, SIFIB exhibited strong anti-inflammatory properties, which based on SIFIB-dependent inhibition of expression and activity of NF-KB and/or concomitant enhanced expression of IKB, a NF-KB-inhibiting protein. Additionally, SIFIB significantly inhibited TGF beta-induced fibroblast differentiation and collagen synthesis as well as effectively reduced TGF-beta synthesis of activated fibroblasts. We have demonstrated wound healing-relevant biological activities of a silica-based bio-degradable inorganic material, which might represent a new therapeutic tool in the treatment of chronic wounds. (C) 2013 Elsevier Ltd. All rights reserved. 
Inflammation; Silica; IL-1 beta; IL-6; IL-8; NF-KB