US EPA

2277010 

Journal Article 

Abstract 

N-demethylation of aminopyrene and p-Chloro-N-methylaniline by isolated perfused rabbit lung 

Armstrong, VL; Niemeier, RW; Bingham, E 

1973 

1 

Toxicology and Applied Pharmacology
ISSN: 0041-008X
EISSN: 1096-0333 

25 

3 

491 

English 

WOS:A1973Q218800146 

is part of a larger document 3114922 Abstracts of papers for the Twelfth Annual Meeting of the Society of Toxicology, New York, New York March 18–22, 1973

The role of the lung in the metabolism of foreign compounds is largely unexplored. An isolated perfused lung was developed in our laboratory (Niemeier and Bingham, 1972) for use in metabolic studies. In addition it is desirable to measure certain physiological changes that may occur in the lung as a result of exposure to pharmacological or environmental agents. The isolated perfused rabbit lung was active in the N-demethylation of aminopyrine (AP) for up to 4 hr of perfusion. p-Chloro-N-methylaniline (PCMA) was more rapidly N-demethylated than AP. It was apparent during the perfusion with the latter compound that methemoglobin formation was occurring. The rate of formation of methemoglobin was followed in this system. The N-demethylation of AP and PCMA was measured also after pretreatment with phenobarbital. 

Twelfth Annual Meeting of the Society of Toxicology 

New York 

March 18–22, 1973