Synthesis and Biological Evaluation of Nitrate Derivatives of Thiocolchicine as Potential Anticancer Drugs | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

2287938

Reference Type

Journal Article

Title

Synthesis and Biological Evaluation of Nitrate Derivatives of Thiocolchicine as Potential Anticancer Drugs

Author(s)

Shen, L; Li, H; Li, S; Bi, H; Xue, B; Lai, Y; Liu, L

Year

2013

Is Peer Reviewed?

Journal

Latin American Journal of Pharmacy
ISSN: 0326-2383

Volume

Issue

Page Numbers

220-224

Web of Science Id

WOS:000331247800011

Abstract

To search for more potent antitumor agent, a series of novel nitric oxide-releasing thiocolchicine derivatives (6a-f and 8a-b) were synthesized by coupling nitrates with thiocolchicine. Their cytotoxicity against four human cancer cell lines (A2780, A549, BEL7402, and MCF7) in vitro were evaluated by MTT assay. Preliminary results indicated that many of the derivatives displayed significant anticancer activities, particularly, compound 8a showed more potent cytotoxic activities than colchicine and thiocolchicine.

Keywords

Colchicine; Thiocolchicine; Nitrates; Cytotoxicity