US EPA

2290747 

Journal Article 

Review 

The interactions of oxidative stress and inflammation with vascular dysfunction in ageing: the vascular health triad 

Wadley, AJ; van Zanten, J; Aldred, S 

2013 

Yes 

Age
ISSN: 0161-9152
EISSN: 1574-4647 

35 

3 

705-718 

English 

22453933 

10.1007/s11357-012-9402-1 

WOS:000318174100015 

http://link.springer.com/10.1007/s11357-012-9402-1
Exit
 

Oxidative stress and inflammation are increased with advancing age. Evidence suggests that oxidative stress and inflammation both lead to impaired vascular function. There is also evidence to suggest that inflammation may cause an increase in radical production leading to enhanced oxidative stress. In addition, oxidative stress may cause an increase in inflammation; however, the interactions between these factors are not fully understood. In this review, we propose the vascular health triad, which draws associations and interactions between oxidative stress and inflammation seen in ageing, and the consequences for vascular function. We review evidence suggesting that exercise may ameliorate the age-related decline in vascular function, through reductions in both oxidative stress and inflammation. 

Reactive oxygen and nitrogen species; Nitric oxide; Free radical; Inflammatory response; Older age; Endothelium