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2299736 
Technical Report 
Variation of the EEG and Some Autonomic Reactions in Cases of Poisoning by Organotin Compounds 
Mazayev, VT; Losev, NI; Voynov, VA 
1968 
NIOSH/00133876 
66 
72-74 
Reactions of the heart, respiratory centers, and cerebral cortex were studied in rabbits poisoned with organotin compounds. Tetraethyltin (597648) and dichlorodibutyltin (683181) were administered through the esophagus in a single dose of 25 milligrams per kilogram (mg/kg) and 100mg/kg, respectively. Reactions of the heart and respiratory tract to ammonia vapors were recorded along with electroencephalogram (EEG) activity. All rabbits developed loss of appetite, adynamia, salivation, and weight loss. Tremors were observed in some. Two animals developed seizures and died from respiratory arrest. All animals died 3 to 7 days after poisoning. There were no detectable changes in the reactions of the heart or respiratory center. The frequency spectrum of the EEG shifted to rapid oscillations, and the amplitude of waves decreased. The authors conclude that the compounds do not intensify reflex reactions. These tin compounds act like anticholinesterase drugs in their mechanism of action. The EEG action may be related to direct central nervous system action or afferent action from the peripheral system. (Russian)