Comparative assessment of the toxic and mutagenic properties of organotin compounds | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

2299984

Reference Type

Journal Article

Title

Comparative assessment of the toxic and mutagenic properties of organotin compounds

Author(s)

Belyaeva, NN; Bystrova, TA; Revazova YU, A; Arkhangel'Skii, VI

Year

1976

Is Peer Reviewed?

Journal

Gigiena i Sanitariya
ISSN: 0016-9900
EISSN: 2412-0650

Report Number

HEEP/78/00573

Issue

Page Numbers

10-14

Abstract

HEEP COPYRIGHT: BIOL ABS. In acute, subacute and chronic experiments of the toxic and mutagenic effects of the common industrial organotin compounds bis(tributyltin) oxide, monobutyltin trilaurate and dibutyltin bis(trifluoroacetate) on mice and rabbits, all 3 compounds demonstrated strong toxic properties, cumulative effect and mutagenic activity. Monobutyltin trilaurate was least biologically active, possibly due to its chemical structure. Morphological, immunological and hematological deviations are noted, including inhibition of enzyme activity, changes of blood composition and chromosome aberration in bone marrow cells.