US EPA

2300552 

Technical Report 

Comparative Toxicology of Organotin Compounds 

Akatsuka, K 

1964 

NIOSH/00133018 

Tokyo 

The toxicology of organic tin compounds was investigated in rabbits, rats, mice, and cats. Compounds were administered through the skin of animals by dropping the compound directly on clipped areas, through the digestive tract in gelatin capsules, through the respiratory tract in a vapor state, and into the eyes by drops. Clinical and histological examinations were performed, including electron microscopy. In rabbits the minimum lethal dose (MLD) for cutaneous administration of tetrabutyltin (1461252) was 2.0 cubic centimeters per kilogram (cc/kg); for the tributyltin monohalides, 0.3 to 0.7cc/kg; and the dibutyltin dihalides, 0.7 to 1.0cc/kg. The MLD for oral administration of tetrabutyltin was greater than 5.0cc/kg; and 0.05 to 0.10cc/kg and 0.05 to 0.15cc/kg for tributyltin monohalides and dibutyltin dihalides, respectively. The MLD for inhalation in mice was 5.15 milligrams per cubic meter (mg/m3) for 2 days at 8 hours per day and 2.12mg/m3 for 6 days at 8 hours per day. Surviving animals had decreases in weight, appetite, red cell counts, hematocrit, and hemoglobin content. Inhalation of tributyltin-bromide (1461230) affected the olfactory sense in cats and the reproductive system in rats. Severe pathological changes were seen in liver and kidneys. Lungs, skin, spleen, thyroid, and adrenal gland were also affected. The changes in surviving animals were mostly reversible.