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2303747 
Journal Article 
SYNTHESIS AND SKIN PERMEATION STUDY OF LIDOCAINE ORGANIC SALTS 
Vajragupta, O; Laong, S 
1994 
Yes 
Drug Development and Industrial Pharmacy
ISSN: 0363-9045
EISSN: 1520-5762 
IPA/95/1082151 
20 
17 
2671-2684 
eng 
WOS:A1994PE76100005 
IPA COPYRIGHT: ASHP Four organic salts of lidocaine were synthesized as prodrugs and skin permeation was studied in vitro using pig skin. The skin permeation of lidocaine adipate and lidocaine malonate after 12 h of application was significantly higher than that of lidocaine hydrochloride, but not significantly different from that of lidocaine. For lidocaine maleate and lidocaine tosylate, the skin permeation was not significantly higher than that of lidocaine hydrochloride at any time. It was concluded that the increased permeability of organic salts of lidocaine may be due to the chemical structure and partition coefficient of the salts contributing ion-pair transportation.