US EPA

2303761 

Journal Article 

Abstract 

Metabolism of intravenously or orally administered butylene glycol adipic acid polyester 

Wright, PL; Levinskas, GJ; Keplinger, ML; Calandra, C 

1974 

1 

Toxicology and Applied Pharmacology
ISSN: 0041-008X
EISSN: 1096-0333 

29 

1 

115 

English 

WOS:A1974T653800109 

is part of a larger document 3378179 Abstracts of papers for the Thirteenth Annual Meeting of the Society of Toxicology, Washington, D.C. March 10–14, 1974

Santicizer® 334F is a linear polyester (1700-2200 average molecular weight) composed of alternating units of adipic acid and 1,3-butylene glycol, terminated by a mixture of myristic, palmitic and stearic acids. The metabolism ofSanticizer 334F containing 1 14C-Iabeled adipate was determined following iv or oral administration. The dose was 3 mg/kg or 2.3 μCi/rat. Partition of excreted 14C between carbon dioxide, urine and feces was nearly identical for iv and orally dosed rats. Of the excreted activity, 50.I % appeared as C02 , 28.6% was in urine and 11.2% was in feces. Tissues, excluding the site of injection and liver, contained 2.6% of the oral dose and 4.8% of the iv dose 96 h post-dosing. Livers from the orally dosed animals contained 0.3% and livers of the iv dosed animals contained 4.6% of the respective doses. Extraction and characterization of the 14C-containing residues in the livers demonstrated that the material was not parent Santicizer 334F. Solvent partition and chromatographic behavior suggested that the residual 14C had been incorporated into naturally occurring cellular compounds. These studies demonstrate that this butylene glycol adipic acid polyester underwent hydrolysis when administered either orally or iv. The subsequent metabolic fate was similar following either route of administration. 

Thirteenth Annual Meeting of the Society of Toxicology 

Washington, D.C. 

March 10–14, 1974