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2305932 
Journal Article 
THE EFFECT OF METHYLCOBALAMIN ON THE TOXICITY OF METHYLMERCURY AND MERCURIC-CHLORIDE ON NERVOUS-TISSUE IN CULTURE 
Kasuya, M 
1980 
1 
Toxicology Letters
ISSN: 0378-4274
EISSN: 1879-3169 
Elsevier 
HEEP/81/05313 
7 
1 
87-93 
English 
7292517 
WOS:A1980KR98000013 
HEEP COPYRIGHT: BIOL ABS. Methylcobalamin (methyl-B12, vitamin B12 analog) at a concentration of 0.2bit the toxic effect of 1 and 1.5ide (MMC) on the development of nerve fibers, glial cells and fibroblasts from newborn rat cerebellum explants. Methyl-B12 at 11.5he toxicity of mercuric chloride (MC) was not significant. These results are in accord with an interaction of alkyl mercurials with membranes of nervous tissue, producing the degenerative changes in the cells, since vitamin B12 increases the lipid synthesis in nervous tissue. The mechanism of toxic action of organic Hg is different from that of inorganic Hg.