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2307997 
Journal Article 
Abstract 
Whole body half-life of methylmercury in adult cats 
Willes, RF; Hollins, JG; Bryce, FR; Charbonneau, SM; Munro, IC; Grice, HC 
1974 
1 
Toxicology and Applied Pharmacology
ISSN: 0041-008X
EISSN: 1096-0333 
29 
1 
137-138 
English 
WOS:A1974T653800166 
is part of a larger document 3378179 Abstracts of papers for the Thirteenth Annual Meeting of the Society of Toxicology, Washington, D.C. March 10–14, 1974
Six adult female cats were given a single oral dose of mercury-203 labelled methylmercury (55 μCi total dose, specific activity 2.0 μCi/mg). Whole body counts were taken daily for 4 days, 3 times weekly until 3 weeks, weekly until 3 months and bi-weekly until 5 months. Twenty-four hr feces and urine collections and hair samples were counted at each of the above time intervals. Five months after dosing, each cat was anesthetized and the total hair was clipped off the body. A whole body count minus hair was taken. The cats were then exsanguinated by cardiac puncture, following which the skin of the cat was removed. A total carcass count was then taken after which the major organs were removed and the mercury-203 in each tissue measured with a crystal scintillation counter. All radioactive counts were corrected for mercury-203 half-life and machine efficiency to allow comparisons between cats and various organs. The average whole body half-life for the 6 cats was calculated as 143.7 ± 2.2 days. This value has not been corrected for excretion into the hair. 
Thirteenth Annual Meeting of the Society of Toxicology 
Washington, D.C. 
March 10–14, 1974