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HERO ID
2327721
Reference Type
Journal Article
Title
Longitudinal effects of fat and lean mass on bone accrual in infants
Author(s)
Sudhagoni, RG; Wey, HE; Djira, GD; Specker, BL
Year
2012
Is Peer Reviewed?
Yes
Journal
Bone
ISSN:
8756-3282
EISSN:
1873-2763
Volume
50
Issue
3
Page Numbers
638-642
Language
English
PMID
22154840
DOI
10.1016/j.bone.2011.11.011
Web of Science Id
WOS:000300650100008
Abstract
There are conflicting reports on the influence of lean and fat mass on bone accrual during childhood. No infant's studies have been reported that describe the influence of changes in body composition with changes in bone accrual during the first year of life. The objective of this research was to test the hypothesis that greater gains in lean mass will have a positive effect on bone mineral content (BMC) accrual, while greater gains in fat mass will have a negative effect on BMC accrual in infants. Longitudinal data from 3 previous infant studies were used. Linear mixed models, adjusting for age, sex, dietary calcium, and length were used to investigate longitudinal and cross-sectional associations between total body BMC and lean and fat mass in the individual studies and in a combined analysis. In both individual and combined analyses, we found that lean and fat mass were positively associated with whole body BMC accrual (all, P<0.001). The cross-sectional association of BMC and dietary calcium was negative in one study (P<0.05). No differences in BMC change between sexes were observed in three studies. Our results showed positive cross-sectional and longitudinal associations between total body BMC and lean mass in infants. In contradiction to our hypothesis for fat mass, we found a positive cross-sectional and longitudinal association between total body BMC and fat mass in infants.
Keywords
DXA; Bone mineral content; Lean mass; Fat mass; Infants
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