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2332123 
Journal Article 
Review 
Inhaled aerosol particle dosimetry in mice: A review (Retracted article) 
Méndez, LB; Gookin, G; Phalen, RF 
2010 
Yes 
Inhalation Toxicology
ISSN: 0895-8378
EISSN: 1091-7691 
22 
12 
1032-1037 
English 
20879957 
WOS:000282627100006 
has erratum 2612161 Inhaled aerosol particle dosimetry in mice: A review (vol 22, pg 1032, 2010)
has retraction 2612161 Inhaled aerosol particle dosimetry in mice: A review (vol 22, pg 1032, 2010)
has other version or edition 3183844 Inhaled aerosol particle dosimetry in mice: A review
The availability of molecular and genetic tools has made the mouse the most common animal model for a variety of human diseases in toxicology studies. However, little is known about the factors that will influence the dose delivery to murine lungs during an inhalation study. Among these factors are the respiratory tract anatomy, lung physiology, and clearance characteristics. Therefore, the objective of this paper is to briefly review the current knowledge on the aforementioned factors in mice and their implications to the dose delivered to mouse models during inhalation studies. Representative scientific publications were chosen from searches using the NCBI PubMed and ISI Web of Knowledge databases. Relevant respiratory physiological differences have been widely reported for different mouse strains and sexes. The limited data on anatomical morphometry that is available for the murine respiratory tract indicates significant differences between mouse strains. These differences have implications to the dose delivered and the biological outcomes of inhalation studies. 
Aerosol; inhalation studies; dosimetry; respiratory tract; mouse