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2453261 
Journal Article 
Congenital taurine deficiency in mice is associated with reduced sensitivity to nociceptive chemical stimulation 
Lötsch, J; Hummel, T; Warskulat, U; Coste, O; Häussinger, D; Geisslinger, G; Tegeder, I 
2014 
Neuroscience
ISSN: 0306-4522
EISSN: 1873-7544 
259 
63-70 
English 
The amino acid taurine is required for development and functioning of the central and peripheral nervous system where it exerts osmoregulatory, neuromodulatory and anti-apoptotic actions. It is subject to cellular import by the taurine transporter slc6a6. Absence of the transporter and consequently, absence of taurine leads to several neurologic deficits and sensory losses. In a slc6a6 knock-out mouse model, consequences of congenital taurine deficiency were assessed in nociceptive sensory processes. The formalin assay, hot plate assay, and summated generator potentials in response to local nociceptive stimulation with gaseous CO2 were applied. Reduced responsiveness of slc6a6(-/-) mice to nociceptive stimulation was observed in particular to chemical nociceptive stimuli. Scl6a6 knock-out mice spent significantly less time licking the formalin injected paw and displayed smaller amplitudes of the nociceptive nasal mucosa potentials than wild-type mice (p=0.002 and 0.01 respectively). In contrast, withdrawal latencies on a hot plate did not significantly differ, suggesting that intracellular taurine deficits lead in particular to a hyposensitivity of nociceptive sensory neurons sensitive to noxious chemical stimulation. As hereditary absence of taurine affects biological processes of anatomical structure development, the altered nociceptive responses likely reflect consequences of compromised peripheral nervous system development. 
pain; knock-out model; mice 
IRIS
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          Reproductive and Developmental Effects
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               PubMed
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     Retroactive RIS import
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               HERO_Formaldehyde_Nervoussystemeffects_SearchUpdate_pid_31_uid_5738Screening091214
               HERO_Formaldehyde_20132014LitSearch_ReproDev_062016
                    Title/Abstract Screen
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     Literature Identification
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          Reproductive and Developmental Effects
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