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Citation
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HERO ID
2453261
Reference Type
Journal Article
Title
Congenital taurine deficiency in mice is associated with reduced sensitivity to nociceptive chemical stimulation
Author(s)
Lötsch, J; Hummel, T; Warskulat, U; Coste, O; Häussinger, D; Geisslinger, G; Tegeder, I
Year
2014
Is Peer Reviewed?
1
Journal
Neuroscience
ISSN:
0306-4522
EISSN:
1873-7544
Volume
259
Page Numbers
63-70
Language
English
PMID
24321512
DOI
10.1016/j.neuroscience.2013.11.037
Web of Science Id
WOS:000330597700008
URL
http://dx.doi.org/10.1016/j.neuroscience.2013.11.037
Exit
Abstract
The amino acid taurine is required for development and functioning of the central and peripheral nervous system where it exerts osmoregulatory, neuromodulatory and anti-apoptotic actions. It is subject to cellular import by the taurine transporter slc6a6. Absence of the transporter and consequently, absence of taurine leads to several neurologic deficits and sensory losses. In a slc6a6 knock-out mouse model, consequences of congenital taurine deficiency were assessed in nociceptive sensory processes. The formalin assay, hot plate assay, and summated generator potentials in response to local nociceptive stimulation with gaseous CO2 were applied. Reduced responsiveness of slc6a6(-/-) mice to nociceptive stimulation was observed in particular to chemical nociceptive stimuli. Scl6a6 knock-out mice spent significantly less time licking the formalin injected paw and displayed smaller amplitudes of the nociceptive nasal mucosa potentials than wild-type mice (p=0.002 and 0.01 respectively). In contrast, withdrawal latencies on a hot plate did not significantly differ, suggesting that intracellular taurine deficits lead in particular to a hyposensitivity of nociceptive sensory neurons sensitive to noxious chemical stimulation. As hereditary absence of taurine affects biological processes of anatomical structure development, the altered nociceptive responses likely reflect consequences of compromised peripheral nervous system development.
Keywords
pain; knock-out model; mice
Tags
IRIS
•
Formaldehyde [archived]
2015 LitSearch
Nervous system effects
WOS
Reproductive and Developmental Effects
WOS
Animal Non-Cancer Respiratory Pathology
PubMed
Search Update
Animal Non-Cancer Respiratory Pathology
2014 LitSearch
Nervous system effects
WOS
Search Update
Reproductive and Developmental Effects
WOS
PubMed
Search Update
Retroactive RIS import
2014
HERO_Formaldehyde_Nervoussystemeffects_2014SearchUpdate_pid_31_uid_5738
HERO_Formaldehyde_Nervoussystemeffects_SearchUpdate_pid_31_uid_5738Screening091214
HERO_Formaldehyde_20132014LitSearch_ReproDev_062016
Title/Abstract Screen
2014-Not About Formaldehyde
2015
HERO_Formaldehyde_AnimalNonCancerRespiratoryPathology_2015SearchUpdate
Title and Abstract Screening
Non-inhalation
•
IRIS Formaldehyde (Inhalation) [Final 2024]
Literature Indexing
PubMed
WoS
Literature Identification
Nervous System Effects
Excluded
Reproductive and Developmental Effects
Excluded
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