US EPA

2453614 

Journal Article 

Autoimmunity caused by xenobiotics 

Bigazzi, PE 

1997 

1 

Toxicology
ISSN: 0300-483X
EISSN: 1879-3185 

BIOSIS/97/14706 

119 

1 

1-21 

English 

BIOSIS COPYRIGHT: BIOL ABS. A number of clinical reports and experimental studies have shown that autoimmune responses and/or autoimmune diseases are induced in humans and laboratory animals by chronic exposure to various chemicals, The present review is focused on the most frequent groups of chemically induced human disorders. Results obtained from studies of the available counterparts of these diseases, i.e., those models obtained from the exposure of laboratory animals to various chemicals are analyzed. Although significant progress has been achieved to the realization that environmental agents may cause profound changes in our immune system and result in autoimmune disease, epidemiological, clinical and experimental work is still needed to acquire a better understanding of the mechanisms involved. 

HEMATOLOGIC DISEASES/PATHOLOGY; HEMATOLOGIC DISEASES/PHYSIOPATHOLOGY; HEMATOPOIETIC SYSTEM/PATHOLOGY; HEMATOPOIETIC SYSTEM/PHYSIOPATHOLOGY; LYMPHATIC DISEASES/PATHOLOGY; LYMPHATIC DISEASES/PHYSIOPATHOLOGY; RETICULOENDOTHELIAL SYSTEM/PATHOLOGY; RETICULOENDOTHELIAL SYSTEM/PHYSIOPATHOLOGY; MUSCULAR DISEASES/PATHOLOGY; MUSCULAR DISEASES/PHYSIOPATHOLOGY; ADIPOSE TISSUE/PATHOLOGY; ADIPOSE TISSUE/PHYSIOPATHOLOGY; BONE DISEASES/PATHOLOGY; BONE DISEASES/PHYSIOPATHOLOGY; CONNECTIVE TISSUE DISEASES/PATHOLOGY; CONNECTIVE TISSUE DISEASES/PHYSIOPATHOLOGY; FASCIA/PATHOLOGY; FASCIA/PHYSIOPATHOLOGY; JOINT DISEASES/PATHOLOGY; JOINT DISEASES/PHYSIOPATHOLOGY; SKIN DISEASES/PATHOLOGY; POISONING; ANIMALS, LABORATORY; PHARMACEUTICAL PREPARATIONS/TOXICITY; IMMUNITY, CELLULAR; HOMINIDAE; Muscle-Pathology; Integumentary System-Pathology; Toxicology-General; Toxicology-Pharmacological Toxicology (1972- ); Immunology and Immunochemistry-Immunopathology; 75330-75-5; 74381-53-6; 62571-86-2; 51481-61-9; 40180-04-9; 37517-30-9; 37350-58-6; 31879-05-7; 29122-68-7; 26921-17-5; 24939-03-5; 20830-75-5; 18883-66-4; 13523-86-9; 12789-03-6; 11056-06-7; 10043-49-9; 9005-49-6; 7553-56-2; 7440-66-6; 7440-50-8; 7440-47-3; 7440-43-9; 7440-22-4; 7440-21-3; 7439-97-6; 7439-93-2; 6673-35-4; 6452-71-7; 5429-85-6; 4685-14-7; 1953-02-2; 1951-25-3; 1934-21-0; 1921-70-6; 1131-64-2; 599-79-1; 555-30-6; 543-38-4; 497-98-3; 484-23-1; 315-30-0; 302-01-2; 298-46-4; 151-67-7; 127-69-5; 127-48-0; 127-18-4; 126-07-8; 113-59-7; 96-24-2; 90-49-3; 86-54-4; 80-08-0; 79-01-6; 77-67-8; 77-36-1; 75-01-4; 73-22-3; 72-57-1; 72-14-0; 67-20-9; 65-49-6; 64-17-5; 62-44-2; 61-68-7; 59-92-7; 57-41-0; 56-49-5; 55-65-2; 54-85-3; 51-71-8; 51-52-5; 51-06-9; 50-53-3; 50-33-9; 50-12-4; 50-06-6; 50-00-0