US EPA

2459239 

Journal Article 

Effect of Ibuprofen, a prostaglandin blocker, on the adrenal hormones of the pigeon during stress 

Sarkar, S; Sengupta, S; Dasadhikari, S; Ghosh, S; Ghosh, A 

1996 

1 

National Academy Science Letters
ISSN: 0250-541X
EISSN: 2250-1754 

19 

5-6 

129-131 

WOS:A1996VG54300007 

The effect of Ibuprofen, a propionic acid derived prostaglandin (PG) blocker on the adrenal hormones was studied during acute stress condition in pigeon (Columba livia). The study reveals that formalin stress depleted the level of epinephrine (E) and increased the corticosterone content of the pigeon adrenal gland. Normally ibuprofen has no effects on the cotecholamine and corticosterone contents of the pigeon adrenal whereas under acute stress condition ibuprofen significantly reduced the adrenal norepinephrine content but showed no influence on E and corticosterone. Such changes differ from the effects of indomethacin, a methylated indole derived PG blocker studied previously in our laboratory. This suggests that chemically and structurally different PG inhibitors show diverse action on the same avian species under similar stress condition. 

prostaglandin; ibuprofen; catecholamine; corticosterone; pigeon