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2571666 
Journal Article 
Correlation of specific IgE to shrimp with cockroach and dust mite exposure and sensitization in an inner-city population 
Wang, J; Calatroni, A; Visness, CM; Sampson, HA 
2011 
Yes 
Journal of Allergy and Clinical Immunology
ISSN: 0091-6749
EISSN: 1097-6825 
128 
4 
834-837 
English 
21872304 
WOS:000296538100021 
BACKGROUND: Studies have demonstrated that IgE-binding cross-reactive epitopes between shrimp, cockroach, and house dust mite tropomyosins can account for the presence of detectable IgE to shrimp in patients with cockroach and dust mite allergies.

OBJECTIVE: We investigated the correlation between IgE-mediated sensitization to shrimp, cockroach, and dust mite in relation to allergen exposure in inner-city children.

METHODS: Five hundred four serum samples from the National Cooperative Inner-City Asthma Study were evaluated for specific IgE to shrimp, and the results were compared with specific IgE to cockroach (Blattella germanica) and dust mite (Dermatophagoides farinae). Associations between IgE sensitization to these allergens and environmental exposures were determined.

RESULTS: There was a strong positive correlation between shrimp, cockroach, and dust mite IgE levels. High exposure to cockroach (B germanica) in the home, particularly in the bedroom and television room, was significantly correlated with higher shrimp and cockroach IgE levels. In contrast, high exposure to dust mite in the home was highly correlated with IgE levels to D farinae but not with shrimp IgE levels. There is a synergistic relationship between cockroach IgE levels and exposure in predicting shrimp IgE levels.

CONCLUSIONS: For children with evidence of IgE-mediated sensitization to cockroach and shrimp, having high exposure to cockroach in the home can contribute to higher shrimp IgE levels, which might not correlate with clinical reactivity. Further patient evaluations with clinical histories of shrimp exposure and reactions, as well as oral food challenges, would have to be performed to confirm these findings. 
Cockroach; dust mite; shrimp; tropomyosin; cross-reactivity