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2575554 
Journal Article 
Review 
Critical factors in the release of drugs from sustained release hydrophilic matrices 
Maderuelo, C; Zarzuelo, A; Lanao, JM 
2011 
Yes 
Journal of Controlled Release
ISSN: 0168-3659
EISSN: 1873-4995 
154 
1 
2-19 
English 
21497624 
WOS:000294143500002 
Hydrophilic matrix systems are one of the most interesting drug delivery systems, and they are currently some of the most widely used to control the release rate of drugs. There are too much factors involved in drug release from hydrophilic matrix systems. The most important factors to be taken into account when developing a formulation based on hydrophilic matrices are the percentage, solubility and drug particle size; the type of polymer, the percentage incorporated, its degree of viscosity and the polymer particle size. Also important are the drug/polymer ratio and the amount of water entering the matrix. Other factors have been shown to be involved in the release of drugs, such as the percentage and mixtures of polymers and the dimensions of the matrix. The compression force is important among the formulation factors to the extent that it determines the amount of air trapped in the matrix. Knowledge of these factors involved in the release of the drugs is crucial for the optimal development of formulations based on hydrophilic systems. 
Sustained release formulations; Release rate; Hydrophilic matrices; Drug delivery; Review