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2581653 
Journal Article 
Indacaterol once-daily is equally effective dosed in the evening or morning in COPD 
Magnussen, H; Verkindre, C; Jack, D; Jadayel, D; Henley, M; Woessner, R; Higgins, M; Kramer, B; INPUT study investigators 
2010 
1 
Respiratory Medicine
ISSN: 0954-6111
EISSN: 1532-3064 
104 
12 
1869-1876 
English 
20850959 
WOS:000284812900017 
UNLABELLED: Indacaterol is a novel, inhaled, long-acting β(2)-agonist providing 24-h bronchodilation with once-daily (o.d.) dosing in patients with COPD. In this double-blind, incomplete block crossover study, patients with moderate-to-severe COPD were randomised to receive three treatment cycles from: indacaterol 300 μg o.d. dosed PM or AM, salmeterol 50 μg twice daily or placebo, each for 14 days. Trough FEV(1) was measured 24 h after indacaterol, and 12 h after salmeterol. Ninety-six patients (mean age: 64 years; post-bronchodilator FEV(1) 57% predicted, FEV(1)/FVC 55%) were randomised; 83 completed. After 14 days, the difference vs. placebo in trough FEV(1) for PM indacaterol was 200 mL (p < 0.001 [primary analysis]) and for AM indacaterol was 200 mL (p < 0.001). Compared with salmeterol, trough FEV(1) for PM indacaterol was 110 mL higher (p < 0.001), and for AM indacaterol was 50 mL higher (p = NS). Over 14 days, vs. placebo, both PM and AM indacaterol improved the % of nights with no awakenings (by 11.9 and 8.1 points; p < 0.01); the % of days with no daytime symptoms (by 6.7 and 5.5 points; p < 0.05); and the % of days able to perform usual activities (by 6.7 and 7.8 points; p < 0.05). Indacaterol provided 24-h bronchodilation and improvement in symptoms regardless of whether taken regularly in the morning or evening.

CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov NCT00615030. 
Chronic obstructive pulmonary disease; Evening dose; Indacaterol; Morning dose; Salmeterol