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2582171 
Journal Article 
Distributed lag non-linear models 
Gasparrini, A; Armstrong, B; Kenward, MG 
2010 
1 
Statistics in Medicine
ISSN: 0277-6715
EISSN: 1097-0258 
29 
21 
2224-2234 
English 
20812303 
WOS:000281506300006 
Environmental stressors often show effects that are delayed in time, requiring the use of statistical models that are flexible enough to describe the additional time dimension of the exposure-response relationship. Here we develop the family of distributed lag non-linear models (DLNM), a modelling framework that can simultaneously represent non-linear exposure-response dependencies and delayed effects. This methodology is based on the definition of a 'cross-basis', a bi-dimensional space of functions that describes simultaneously the shape of the relationship along both the space of the predictor and the lag dimension of its occurrence. In this way the approach provides a unified framework for a range of models that have previously been used in this setting, and new more flexible variants. This family of models is implemented in the package dlnm within the statistical environment R. To illustrate the methodology we use examples of DLNMs to represent the relationship between temperature and mortality, using data from the National Morbidity, Mortality, and Air Pollution Study (NMMAPS) for New York during the period 1987-2000. 
distributed lag; time series; smoothing; delayed effects