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HERO ID
2584740
Reference Type
Journal Article
Subtype
Review
Title
Cadmium exposure in the population: from health risks to strategies of prevention
Author(s)
Nawrot, TS; Staessen, JA; Roels, HA; Munters, E; Cuypers, A; Richart, T; Ruttens, A; Smeets, K; Clijsters, H; Vangronsveld, J
Year
2010
Is Peer Reviewed?
Yes
Journal
BioMetals
ISSN:
0966-0844
EISSN:
1572-8773
Volume
23
Issue
5
Page Numbers
769-782
Language
English
PMID
20517707
DOI
10.1007/s10534-010-9343-z
Web of Science Id
WOS:000283079200002
Abstract
We focus on the recent evidence that elucidates our understanding about the effects of cadmium (Cd) on human health and their prevention. Recently, there has been substantial progress in the exploration of the shape of the Cd concentration-response function on osteoporosis and mortality. Environmental exposure to Cd increases total mortality in a continuous fashion without evidence of a threshold, independently of kidney function and other classical factors associated with mortality including age, gender, smoking and social economic status. Pooled hazard rates of two recent environmental population based cohort studies revealed that for each doubling of urinary Cd concentration, the relative risk for mortality increases with 17% (95% CI 4.2-33.1%; P < 0.0001). Tubular kidney damage starts at urinary Cd concentrations ranging between 0.5 and 2 μg urinary Cd/g creatinine, and recent studies focusing on bone effects show increased risk of osteoporosis even at urinary Cd below 1 μg Cd/g creatinine. The non-smoking adult population has urinary Cd concentrations close to or higher than 0.5 μg Cd/g creatinine. To diminish the transfer of Cd from soil to plants for human consumption, the bioavailability of soil Cd for the plants should be reduced (external bioavailability) by maintaining agricultural and garden soils pH close to neutral (pH-H(2)O of 7.5; pH-KCL of 6.5). Reducing the systemic bioavailability of intestinal Cd can be best achieved by preserving a balanced iron status. The latter might especially be relevant in groups with a lower intake of iron, such as vegetarians, and women in reproductive phase of life. In exposed populations, house dust loaded with Cd is an additional relevant exposure route. In view of the insidious etiology of health effects associated with low dose exposure to Cd and the current European Cd intake which is close to the tolerable weekly intake, one should not underestimate the importance of the recent epidemiological evidence on Cd toxicity as to its medical and public health implications.
Keywords
Cadmium; Epidemiology; Kidney; Prevention; Mortality; Osteoporosis; Toxic metals
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