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2586407 
Journal Article 
The release behavior of doxorubicin hydrochloride from medicated fibers prepared by emulsion-electrospinning 
Xu, X; Chen, X; Ma, P; Wang, X; Jing, X 
2008 
1 
European Journal of Pharmaceutics and Biopharmaceutics
ISSN: 0939-6411
EISSN: 1873-3441 
70 
1 
165-170 
18472256 
WOS:000259742600018 
The release behavior of a water-soluble small molecule drug from the drug-loaded nanofibers prepared by emulsion-electrospinning was investigated. Doxorubicin hydrochloride (Dox), a water-soluble anticancer agent, was used as the model drug. The laser scanning confocal microscopic images indicated that the drug was well incorporated into amphiphilic poly(ethylene glycol)-poly(L-lactic acid) (PEG-PLA) diblock copolymer nanofibers, forming "core-sheath" structured drug-loaded nanofibers. The drug release behavior of this drug-loaded system showed a three-stage diffusion-controlled mechanism, in which the release rate of the first stage was slower than that of the second stage, but both obeyed Fick's second law. Based on these results, it is concluded that the Dox-loaded fibers prepared by emulsion-electrospinning represent a reservoir-type delivery system in which the Dox release rate decreases with the increasing Dox content in the fibers. (c) 2008 Elsevier B.V. All rights reserved. 
emulsion; electrospinning; nanofiber; drug delivery; diffusion