Health & Environmental Research Online (HERO)


Print Feedback Export to File
2586571 
Journal Article 
Review 
Relationships between plasma membrane microdomains and HIV-1 assembly 
Ono, A 
2010 
Yes 
Biology of the Cell
ISSN: 0248-4900
EISSN: 1768-322X 
102 
6 
335-350 
English 
20356318 
WOS:000278794200002 
Advances in cell biology and biophysics revealed that cellular membranes consist of multiple microdomains with specific sets of components such as lipid rafts and TEMs (tetraspanin-enriched microdomains). An increasing number of enveloped viruses have been shown to utilize these microdomains during their assembly. Among them, association of HIV-1 (HIV type 1) and other retroviruses with lipid rafts and TEMs within the PM (plasma membrane) is well documented. In this review, I describe our current knowledge on interrelationships between PM microdomain organization and the HIV-1 particle assembly process. Microdomain association during virus particle assembly may also modulate subsequent virus spread. Potential roles played by microdomains will be discussed with regard to two post-assembly events, i.e., inhibition of virus release by a raft-associated protein BST-2/tetherin and cell-to-cell HIV-1 transmission at virological synapses. 
Gag; lipid raft; phosphatidylinositol 4,5-bisphosphate; plasma membrane; tetherin; tetraspanin