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2612471 
Journal Article 
Abstract 
Vascular function in diabetic individuals in association with particulate matter 
Schneider, AE; Siponen, T; Hampel, R; Breitner, S; Kraus, U; Neas, LM; Herbst, M; Hinderliter, A; Cascio, W; Peters, A; Devlin, RB 
2010 
Yes 
American Journal of Respiratory and Critical Care Medicine
ISSN: 1073-449X
EISSN: 1535-4970 
181 
A1710 
English 
WOS:000208771000710 
is part of a larger document 3452678 Proceedings of the American Thoracic Society 2010 International Conference, May 14-19, 2010, New Orleans
Rationale: Exposure to ambient air pollution modulates cardiovascular effects, especially in people with chronic diseases such as diabetes. The purpose of this study was to analyze the short-term effects of air pollution on vascular function in two panels consisting of individuals with type-2 diabetes exposed to a North American or European airshed.

Methods: A prospective panel study with 4 repeated measurements was conducted on 22 individuals in Chapel Hill, NC between Nov 2004 and Dec 2005. Daily measurements of PM2.5 and meteorological data were acquired on the rooftop of the exam site. Another panel study with similar design was conducted on 33 individuals in Augsburg, Germany, for the period Mar 2007 to Dec 2008. Hourly measurements of air pollution and meteorology were performed at a central measurement site and individual 24-hour-averages were calculated. In both panels, measurements of blood pressure (BP) and endothelial function were conducted. Data were analyzed using mixed models with random patient effects adjusting for trend, day of the week and meteorology.

Results: In the Chapel Hill panel, systolic BP (BPsys) showed a borderline decrease in association with an increase of 10µg/m³ in same-day PM2.5 exposure (%-change: -2.7%; 95%-confidence interval: [-5.5%; 0.1%]) and together with diastolic BP (BPdia) an increase with a delay of four days (BPsys: 2.6% [0.0%; 5.3%]; BPdia: ). In the Augsburg panel, BPsys results also suggested an immediate decrease (-2.3% [-5.1%; 0.5%]); however, only BPdia decreased significantly within the first 24 hours (-3.0% [-5.4%; -0.5%]) in association with an increase of 10µg/m³ in PM2.5 exposure. A comparative analysis of endothelial function measurements in both panels is ongoing.

Conclusions: The data suggest an immediate as well as a delayed association between air pollution exposure and blood pressure in diabetic individuals. These findings add to the discussion on blood pressure effects induced by air pollution and to the concept of susceptibility due to underlying chronic diseases. 
American Thoracic Society 2010 International Conference 
New Orleans, LA 
May 14-19, 2010