Multiwalled Carbon Nanotubes Hinder Microglia Function Interfering with Cell Migration and Phagocytosis | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

2643258

Reference Type

Journal Article

Title

Multiwalled Carbon Nanotubes Hinder Microglia Function Interfering with Cell Migration and Phagocytosis

Author(s)

Villegas, JC; Alvarez-Montes, L; Rodriguez-Fernandez, L; Gonzalez, J; Valiente, R; Fanarraga, ML

Year

2014

Volume

Issue

Page Numbers

424-432

Language

English

PMID

23950018

DOI

10.1002/adhm.201300178

Web of Science Id

WOS:000332336400014

Abstract

The intranasal drug delivery route provides exciting expectations regarding the application of engineered nanomaterials as nano-medicines or drug-delivery vectors into the brain. Among nanomaterials, multiwalled CNTs (MWCNTs) are some of the best candidates for brain cancer therapy since they are well known to go across cellular barriers and display an intrinsic ability to block cancer cell proliferation triggering apoptosis. This study reveals that microglial cells, the brain macrophages and putative vehicles for MWCNTs into the brain, undergo a dose-dependent cell division arrest and apoptosis when treated with MWCNTs. Moreover, it is shown that MWCNTs severely interfere with both cell migration and phagocytosis in live microglia. These results lead to a re-evaluation of the safety of inhaled airborne CNTs and provide strategic clues of how to biocompatibilize MWCNTs to reduce brain macrophage damage and to develop new nanodrugs.

Keywords

carbon nanotubes; apoptosis; proliferation; migration; phagocytosis