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2654774 
Journal Article 
PATHOLOGIC FINDINGS OF ANTHRACO-SILICOSIS IN THE LUNGS OF ONE HUMPED CAMELS (Camelus dromedarius) 
Goodarzi, M; Azizi, S; Koupaei, MJ; Moshkelani, S 
2013 
Yes 
Journal of Camel Practice and Research
ISSN: 0971-6777 
20 
1 
93-96 
WOS:000325836200019 
This study was designed to describe the gross and histopathological features of pneumoconiosis in the lungs and its relation with the occurrence of pneumonia in camels. 150 pneumonic and 100 healthy lungs were examined for pneumoconiosis, histopathologically. Pneumoconiosis was diagnosed in 43 out of 150 lungs with pneumonic lesions. Macroscopic lesions of pneumoconiotic lungs were related to pneumonia and no remarkable features of pneumoconiosis were observed in the examined tissues. Out of 43 pneumoconiotic lungs, 93% (n=40/43) were associated with interstitial pneumonia. Pneumoconiosis occurred in 2.32% (n=1/43) and 4.65% (n=2/43) lungs with suppurative bronchopneumonia and bronchointerstitial pneumonia, respectively. Histopathologic findings revealed by varying degrees of diffuse to nodular fibrosis associated with mild to heavy accumulations of mixed carbon and silicon dusts. Interlobular and interalveolar septa were thickened by fibrosis and infiltration of mononuclear inflammatory cells. Crystalline silicon particles were in different shapes including filamentous, oblong and polygonal. Anthraco-silicosis particles were observed inside and outside of macrophages more adjacent to the vessels and bronchioles as well as lymphocytes infiltration. The particle aggregations appeared scanty gray to brown or dense black, depending on the amount of silicon or carbon dust. In the lungs, the areas with prominent deposition of crystalline silica rather than carbon were gray to light brown and focal interstitial fibrosis occurred. The present study suggests a positive causal relationship between pneumoconiosis and pneumonia. It seems these particles predispose animals to pulmonary diseases especially various type of pneumonia. 
Anthracosis; camel; human; pathology; pneumoconiosis; silicosis