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2661410 
Journal Article 
"Design Space" Determination of a Paracetamol Fluid Bed Granulation Using Design of Experiments 
Hartung, A; Johansson, E; Knoell, M; Valthorsson, H; Langguth, P 
2012 
74 
4 
644-650 
WOS:000303784200005 
This study was performed to increase understanding of a paracetamol fluid bed granulation process and to identify the critical process parameters in a laboratory scale granulation process. The screening of the process parameters and their influence on final granules quality attributes were investigated using a factorial design. For this purpose the process parameters were first screened and depicted by the Ishikawa diagram. The experimental runs performed, given by the design model, identified spray rate followed by inlet air flow and atomizing spray pressure as the critical process parameters. Trials with high spray rates lead to granules with excellent flow properties. Furthermore, by increasing the inlet air volume granules with tight particle size distribution were obtained. 
Design of experiments; Design space; Fluid bed granulation; Paracetamol; Quality by design