US EPA

2669274 

Journal Article 

Occupational Asbestos Exposure as a Risk Factor for Laryngeal Carcinoma in a Population-Based Case-Control Study from Germany 

Ramroth, H; Ahrens, W; Dietz, A; Becher, H 

2011 

Yes 

American Journal of Industrial Medicine
ISSN: 0271-3586
EISSN: 1097-0274 

54 

7 

510-514 

English 

21538446 

10.1002/ajim.20963 

WOS:000291898300002 

Background As several studies have identified asbestos exposure as an independent occupational risk factor for laryngeal cancer, the aim of our study was to confirm this association.



Methods In a population-based case-control study on laryngeal cancer in South-West Germany occupational exposures and other risk factors were obtained by face-to-face interviews using a detailed standardized questionnaire covering the complete individual working history, supplemented by job-specific questionnaires (JSQ) especially for selected jobs known to entail exposure to asbestos. Detailed exposure information was collected over a wide range of asbestos related jobs and branches and analyzed using different modeling strategies.



Results Seventy-three (28.4%) cases and 158 (20.5%) controls reported any exposure to asbestos. Elevated risk estimates for asbestos exposure were found. However, those became substantially reduced after adjustment for smoking and alcohol.



Conclusion Moderately elevated risks for laryngeal cancer after exposure to asbestos were confirmed. Difficulties in the collection of adequate exposure data were demonstrated. Am. J. Ind. Med. 54:510-514, 2011. (C) 2011 Wiley-Liss, Inc. 

laryngeal cancer; occupational exposure; asbestos; detailed measurement methods