Health & Environmental Research Online (HERO)


Print Feedback Export to File
2673814 
Journal Article 
Osteoconductive hydroxyapatite coated PEEK for spinal fusion surgery 
Hahn, BD; Park, DSoo; Choi, JJin; Ryu, J; Yoon, WHa; Choi, JH; Kim, JWoo; Ahn, CWoo; Kim, HEe; Yoon, BHo; Jung, InK 
2013 
Yes 
Applied Surface Science
ISSN: 0169-4332 
283 
6-11 
WOS:000323601700002 
Polyetheretherketone (PEEK) has attracted much interest as biomaterial for interbody fusion cages due to its similar stiffness to bone and good radio-transparency for post-op visualization. Hydroxyapatite (HA) coating stimulates bone growth to the medical implant. The objective of this work is to make an implant consisting of biocompatible PEEK with an osteoconductive HA surface for spinal or orthopedic applications. Highly dense and well-adhered HA coating was developed on medical-grade PEEK using aerosol deposition (AD) without thermal degradation of the PEEK. The HA coating had a dense microstructure with no cracks or pores, and showed good adhesion to PEEK at adhesion strengths above 14.3 MPa. The crystallinity of the HA coating was remarkably enhanced by hydrothermal annealing as post-deposition heat-treatment. In addition, in vitro and in vivo biocompatibility of PEEK, in terms of cell adhesion morphology, cell proliferation, differentiation, and bone-to-implant contact ratio, were remarkably enhanced by the HA coating through AD. (c) 2013 Elsevier B.V. All rights reserved. 
PEEK; Hydroxyapatite; Aerosol deposition; Adhesion strength; Biocompatibility