US EPA

2720106 

Journal Article 

Abstract 

Reproduction and teratology studies with the fungicide ferbam 

Minor, JL; Russell, JQ; Lee C-C 

1974 

1 

Toxicology and Applied Pharmacology
ISSN: 0041-008X
EISSN: 1096-0333 

29 

1 

120 

English 

is part of a larger document 3378179 Abstracts of papers for the Thirteenth Annual Meeting of the Society of Toxicology, Washington, D.C. March 10–14, 1974

The reproductive and teratogenic effects of the fungicide, ferric dimethyldithiocarbamate (ferbam), were studied in rodents. Daily feeding, equivalent to 23, 66 or 109 mg/kg/day, to male rats for 13 weeks caused deaths and weight loss at the highest dosage without any effect on reproduction. Daily feeding, equivalent to 15 or 51 mg/kg/day, to females for 2 weeks caused a severe weight loss at the high dose and a slight, but not significant, decrease in neonatal survival. Ferbam, administered to rats on days 6-15 of gestation at dosage of 150 mg/kg/ day resulted in some deaths, increased resorption, decreased fetal weight, and caused a slight increase in soft and skeletal tissue anomalies. Ferbam, administered to mice on days 6-14 of gestation at 30 or 300 mg/kg/day, failed to show any teratologic affect. These studies suggest that high doses of ferbam caused mild teratologic effects in rats. (Supported by the National Institute of Environmental Health Sciences, Contract No. NIH-NIEHS-72-2084.) 

Thirteenth Annual Meeting of the Society of Toxicology 

Washington, D.C. 

March 10–14, 1974