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2722822 
Technical Report 
Comparative studies on the pharmacokinetics of the antihistaminic fenkarol and its o-tolyl congener 
Chumburidze, TB; Kaminka, ME; Spryshkova, RA 
1982 
IPA/84/558186 
Chem 
USSR 
699-702 
English 
IPA COPYRIGHT: ASHP The pharmacokinetics of single and multiple doses of fenkarol (phencarol) and a congener, quinuclidyl-3-di(o-tolyl)carbinol (bikarfen) were investigated following intragastric administration to rats, and the resultant data were correlated to the duration of action of the drugs. Total body distribution was similar for both drugs. Phencarol was eliminated mainly by urinary excretion, while single doses of the derivative were excreted mainly by the intestine. Multiple administration of the derivative enhanced urinary excretion. The half-life, and subsequently the duration of action, of the derivative was longer than phencarol.