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HERO ID
2724572
Reference Type
Technical Report
Title
Embryonic toxicity of DI-Ku-Shuang (Bis-A-TDA) on Drosophila melanogaster and the detoxication of niacinamide
Author(s)
Zeng, F; Wang, F; Xiao, Y; Zhang, J
Year
1990
Report Number
BIOSIS/93/00279
Volume
ZIRAN KEXUEBAN
Issue
ZIRAN KEXUEBAN
Page Numbers
343-347
Language
Chinese
Abstract
BIOSIS COPYRIGHT: BIOL ABS. The known teratogen, Bis-A-TDA (N, N'-Methylene-bis (2-amino-1, 3, 4-thiadiazole)), was tested for influence on embryonic development of Drosophila melanogaster. Treatment consisted of rearing the fly larvae in media containing Bis-A-TDA concentrations of 0, 10, 100, 150, 200, 250, 350, 500, 750 and 1000 ppm. Emerging flies were counted and inspected for gross malformation. Toxicity inhibition test was conducted with medium containing inhibitor-niacinamide and Bis-A-TDA both on concentration of 200 ppm. The results show: there is a line relationship between the embryonic toxicity of Bis-A-TDA and its dosage. When the dosage rises from 150 to 350 ppm, the number of emerging flies decreases and malformation flies increase dramatically. Among larvae, pupa and adult fly, pupa is most sensitive to Bis-A-TDA; niacinamide can partly inhibit the embryonic toxicity of Bis-A-TDA in D. melanogaster; low concentration of Bis-A-TDA (10 to 100 ppm) can enhance embryonic development of
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