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2724572 
Technical Report 
Embryonic toxicity of DI-Ku-Shuang (Bis-A-TDA) on Drosophila melanogaster and the detoxication of niacinamide 
Zeng, F; Wang, F; Xiao, Y; Zhang, J 
1990 
BIOSIS/93/00279 
ZIRAN KEXUEBAN 
ZIRAN KEXUEBAN 
343-347 
Chinese 
BIOSIS COPYRIGHT: BIOL ABS. The known teratogen, Bis-A-TDA (N, N'-Methylene-bis (2-amino-1, 3, 4-thiadiazole)), was tested for influence on embryonic development of Drosophila melanogaster. Treatment consisted of rearing the fly larvae in media containing Bis-A-TDA concentrations of 0, 10, 100, 150, 200, 250, 350, 500, 750 and 1000 ppm. Emerging flies were counted and inspected for gross malformation. Toxicity inhibition test was conducted with medium containing inhibitor-niacinamide and Bis-A-TDA both on concentration of 200 ppm. The results show: there is a line relationship between the embryonic toxicity of Bis-A-TDA and its dosage. When the dosage rises from 150 to 350 ppm, the number of emerging flies decreases and malformation flies increase dramatically. Among larvae, pupa and adult fly, pupa is most sensitive to Bis-A-TDA; niacinamide can partly inhibit the embryonic toxicity of Bis-A-TDA in D. melanogaster; low concentration of Bis-A-TDA (10 to 100 ppm) can enhance embryonic development of