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2725349 
Journal Article 
Amlodipine vs nifedipine retard: evaluation of efficacy and tolerability using ambulatory blood pressure monitoring 
Bossini, A; Di Veroli, C; Germano, U; Monteverde, A; Cagli, V; Et al 
1997 
Yes 
Clinical Drug Investigation
ISSN: 1173-2563 
IPA/98/1154093 
Drug Invest 
REF 15 
English 
IPA COPYRIGHT: ASHP To compare the efficacy and tolerability of amlodipine and nifedipine retard, a 3 month, open parallel comparative study was conducted in 60 outpatients, mean age 50 yr, with mild to moderate essential hypertension who received either amlodipine 5 mg once daily or nifedipine retard 20 mg twice daily (if satisfactory blood pressure control had not been achieved after 4 wk of treatment, doses were doubled to amlodipine 10 mg once daily and nifedipine retard to 40 mg twice daily). Data from 24 h ambulatory blood pressure monitoring confirmed that both drugs produced good blood pressure control. However, more significant and persistent reductions were observed with amlodipine, which may be due to the sustained plasma concentrations produced by this drug. Patients treated with amlodipine also experienced fewer adverse effects than the nifedipine group.