Characterization of the enantiomeric 3-substituted-1,4-benzodiazepin-2-ones binding to the GABA-BDZ-chloride ionophore receptor complex | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

2725629

Reference Type

Journal Article

Title

Characterization of the enantiomeric 3-substituted-1,4-benzodiazepin-2-ones binding to the GABA-BDZ-chloride ionophore receptor complex

Author(s)

Bertucci, C; Salvadori, P; Belfiore, S; Martini, C; Lucacchini, A

Year

1992

Is Peer Reviewed?

Yes

Journal

Journal of Pharmaceutical and Biomedical Analysis
ISSN: 0731-7085
EISSN: 1873-264X

Report Number

IPA/93/1021224

Volume

Pharm

Issue

REF 33

Page Numbers

359-363

Language

English

Abstract

IPA COPYRIGHT: ASHP The receptor interaction of a series of chiral 3-substituted-1,4-benzodiazepin-2-ones, resolved as pure enantiomers by preparative chiral HPLC, is described. The study of the interaction of the benzodiazepine receptor with the GABA receptor and chloride channel was utilized to profile the in vitro differences between enantiomeric benzodiazepines as agonists, antagonists, and inverse agonists.