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2725961 
Technical Report 
Fentrifanil: a diarylamine acaricide with potent mitochondrial uncoupling activity 
Nizamani, SM; Hollingworth, RM 
1980 
Yes 
Biochemical and Biophysical Research Communications
ISSN: 0006-291X
EISSN: 1090-2104 
PESTAB/81/0164 
Biophys 
2 
704-710 
English 
7426009 
WOS:A1980KK77400025 
PESTAB. Studies on an acaricide with mitochondrial uncoupling activity [fentrifanil; 2'-chloro-2,4-dinitro-5',6-di(trifluoromethyl)-diphenylamine] are presented. Isolated mitochondria (from mice livers) were incubated with fentrifanil, and oxygen uptake was measured polarographically using a Clark oxygen electrode. The ADP ratio, respiratory control index (RCI), and stimulation of state 4 respiration were also measured. Fentrifanil was found to stimulate oxygen consumption, reduce the RCI, lower the ADP/O ratio, and release the oligomycin block of ADP-stimulated respiration. In terms of the concentration required to decrease the RCI value by 50%, fentrifanil was about 4500-fold more potent than 2,4-dinitrophenol and slightly more potent than carbonylcyanide m-chlorophenylhydrazone (MCCP).